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Title: Aqueous extract of Ficus religiosa Linn. reduces oxidative stress in experimentally induced type 2 diabetic rats
Authors: Kirana, H
Agrawal, S S
Srinivasan, B P
Keywords: Ficus religiosa;Oxidative stress;Rasayana;Type 2 diabetes
Issue Date: Oct-2009
Publisher: CSIR
Abstract: One of the major etiologies in pathogenesis of type 2 diabetes especially complications is oxidative stress. Aqueous extract of Ficus religiosa at a dose of 100 and 200 mg/kg orally decreased the fasting blood glucose in streptozotocin induced type 2 diabetic rats. The drug had enzyme induction effect with respect to catalase (CAT) and glutathione peroxidase (GSH-Px) activity, however decreased the exaggerated activity of superoxide dismutase (SOD) in type 2 diabetic rats. F. religiosa modulated the enzymes of antioxidant defence system to combat oxidative stress. As a result, glutathione (GSH-reduced form) was restored and inhibited the formation of malondialdehyde. Drug at higher dose (200 mg/kg) had more pronounced effect. F. religiosa, a rasayana group of plant drug having anti-diabetic activity along with antioxidant potential was beneficial in treatment of type 2 diabetes.
Page(s): 822-826
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.47(10) [October 2009]

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