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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(10) [October 2009] >
| Title: | Inhibitory effect of Glimepiride on nicotinamide-streptozotocin induced nuclear damages and sperm abnormality in diabetic Wistar rats |
| Authors: | Rabbani, Syed Imam
Devi, Kshama
Khanam, Salma |
| Keywords: | Antioxidant
Glimepiride
Micronucleus
Sperm abnormality |
| Issue Date: | Oct-2009 |
| Publisher: | CSIR |
| Abstract: | The generation
of reactive oxygen species in diabetes is considered to be the major cause for
the mutation related defects such as cancer, infertility etc. Glimepiride (Gmp)
is a third generation antidiabetic sulphonylurea known to possess the
antioxidant effect in streptozotocin (STZ) induced diabetes. In this study, the
anti-mutagenic activity of Gmp (0.175, 17.5 and 175 mg/kg, po daily for 4 weeks)
was evaluated against the nicotinamide (NA-230 mg/kg) and STZ (65 mg/kg)
induced somatic and germinal cells defect using bone marrow micronucleus (MN)
test and sperm abnormality test respectively in male Wistar rats.
Administration of Gmp at 175 mg prevented the NA-STZ induced increased
frequency of MN in polychromatic and normochromatic erythrocytes. The treatment
with Gmp also decreased the sperm shape abnormality and enhanced the sperm
count besides improving the antioxidant status in the diabetic rats. However,
the other doses of Gmp (0.175 and 17.5 mg) did not produce significant change
in the MN frequency and sperm abnormality although Gmp at 17.5 mg showed
significant antidiabetic effect in the hyperglycemic animals. The results
indicated that Gmp inhibited the NA-STZ mediated changes in the MN frequency
and sperm abnormality and enhanced the antioxidant defense. The observations
suggest that the antioxidant property of Gmp could have contributed for its
ability to decrease the NA-STZ mediated defects in somatic and germinal cells. |
| Page(s): | 804-810 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.47(10) [October 2009]
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