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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(10) [October 2009] >
| Title: | Interaction of tapasin related protein with cell surface MHC class 1 heavy chain molecules |
| Authors: | Devasahayam, Mercy |
| Keywords: | Confocal
MHC A2 molecules
Tapasin |
| Issue Date: | Oct-2009 |
| Publisher: | CSIR |
| Abstract: | Tapasin related
(TR) protein shares similarity (27%) with tapasin and is present in endoplasmic
reticulam (ER) and on the cell surface of Hela cells. In the present article,
TR protein was found localized in ER, but not in the lysosomes or late
endosomes as studied by confocal colocalization. TR protein was associated with
cell surface MHC class 1 HLA A2 heavy chain (HC) molecules and might be
involved in chaperoning of cell surface HC MHC class 1 molecule. The results
indicated that MHC class 1 cell surface molecules involved in antigen
presentation of exogenous antigens, interact with cell surface chaperons. |
| Page(s): | 792-798 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.47(10) [October 2009]
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