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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(09) [September 2009] >
| Title: | Design, synthesis and evaluation of diclofenac-antioxidant mutual prodrugs as safer NSAIDs |
| Authors: | Manon, Benu
Sharma, Pritam D |
| Keywords: | NSAIDs
diclofenac
mutual prodrug
antioxidants
ulcerogenicity |
| Issue Date: | Sep-2009 |
| Publisher: | CSIR |
| Abstract: | Diclofenac has been
conjugated with different antioxidants having antiulcerogenic activity with the
objective of obtaining diclofenac-antioxidant mutual prodrugs as safer NSAIDs
devoid of ulcerogenic side-effects. The synthesized derivatives are screened
for their antiinflammatory, analgesic and antiulcer activity. The mutual
prodrugs show retention of antiinflammatory activity with reduced ulcerogenic side-effects.
These results indicate that diclofenac-antioxidant mutual prodrugs have the
potential to be developed as safer NSAIDs |
| Page(s): | 1279-1287 |
| Source: | IJC-B Vol.48B(09) [September 2009]
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