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Title: Design, synthesis and evaluation of diclofenac-antioxidant mutual prodrugs as safer NSAIDs
Authors: Manon, Benu
Sharma, Pritam D
Keywords: NSAIDs;diclofenac;mutual prodrug;antioxidants;ulcerogenicity
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Diclofenac has been conjugated with different antioxidants having antiulcerogenic activity with the objective of obtaining diclofenac-antioxidant mutual prodrugs as safer NSAIDs devoid of ulcerogenic side-effects. The synthesized derivatives are screened for their antiinflammatory, analgesic and antiulcer activity. The mutual prodrugs show retention of antiinflammatory activity with reduced ulcerogenic side-effects. These results indicate that diclofenac-antioxidant mutual prodrugs have the potential to be developed as safer NSAIDs
Page(s): 1279-1287
Appears in Collections:IJC-B Vol.48B(09) [September 2009]

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