25-May-2013
20:21:51 IST
|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(09) [September 2009] >
| Title: | Synthesis and antimicrobial activity of novel ethyl-5-(ethoxycarbonyl)-4-methylthiazol-2-yl-carbamate compounds |
| Authors: | Mruthyunjayaswamy, B H M
Basavarajaiah, S M |
| Keywords: | Thiazole
pyrrazole
oxadiazole-2-thione
substituted oxadiazole
antimicrobial activity |
| Issue Date: | Sep-2009 |
| Publisher: | CSIR |
| Abstract: | Ethyl-2-amino-4-methylthiazol-5-carboxylate 1
on treatment with ethylchloroformate followed by reaction with hydrazine
hydrate gave ethyl-5-(ethoxycarbonyl)-4-methylthiazol-2-yl-carbamate 2 and
4-methylthiazol-2-yl-semicarbazido-5-carboxyhydrazide 3 respectively.
Compound 3 on further reaction with ethyl acetoacetate,
ethylcyanoacetate, acetylacetone, carbondisulphide-potassium hydroxide and
different substituted aromatic acids yielded the corresponding
4-methyl-2-yl-amino-(1-N-carboxyl-3-methyl-4,5-dihydro-1H-pyrazol-5-one)-5-(1-N-carboxyl-3-methyl-4,5-dihydro-1H-pyrazol-5-one)-thiazole
4, 4-methyl-2-yl-amino-(1-N-carboxyl-3-amino-4,5-dihydro-1H-pyrazol-5-one)-5-(1-N-carboxyl-3-amino-4,5-dihydro-1H-pyrazol-5-one)-thiazole
5,4-methyl-2-yl-amino-(1-N-carboxyl-3,5-dimethyl-1H-pyrazol)-5-(1-N-carboxyl-3,5-dimethyl-1H-pyrazol)-thiazole
6, 4-methyl-2-yl-amino-(1,3,4-oxadiazolin-5-thione)-5yl-(1,3,4-oxadiazolin-5-thione-2yl)-thiazole
7 and
4-methyl-2-yl-amino-(5-substituted-1,3,4-oxadiazol-2yl)-5-(5-substituted-1,3,4-oxadiazol-2yl)-thiazole
8a-d, respectively. All the synthesized compounds have been screened for
their antimicrobial activity. |
| Page(s): | 1274-1278 |
| Source: | IJC-B Vol.48B(09) [September 2009]
|
|
