Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6044
Title: Synthesis and antimicrobial activity of novel ethyl-5-(ethoxycarbonyl)-4-methylthiazol-2-yl-carbamate compounds
Authors: Mruthyunjayaswamy, B H M
Basavarajaiah, S M
Keywords: Thiazole
pyrrazole
oxadiazole-2-thione
substituted oxadiazole
antimicrobial activity
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Ethyl-2-amino-4-methylthiazol-5-carboxylate <b>1 </b>on treatment with ethylchloroformate followed by reaction with hydrazine hydrate gave ethyl-5-(ethoxycarbonyl)-4-methylthiazol-2-yl-carbamate <b>2 </b>and 4-methylthiazol-2-yl-semi­carbazido-5-carboxyhydrazide <b>3 </b>respectively. Compound <b>3 </b>on further reaction with ethyl acetoacetate, ethylcyanoacetate, acetylacetone, carbondisulphide-potassium hydroxide and different substituted aromatic acids yielded the corresponding 4-methyl-2-yl-amino-(1-N-carboxyl-3-methyl-4,5-dihydro-<i>1H</i>-pyrazol-5-one)-5-(1-N-carboxyl-3-methyl-4,5-dihydro-<i>1H</i>-pyr­azol-5-one)-thiazole <b>4, </b>4-methyl-2-yl-amino-(1-N-carboxyl-3-amino-4,5-dihydro-<i>1H</i>-pyrazol-5-one)-5-(1-N-carboxyl-3-amino-4,5-dihydro-<i>1H</i>-pyrazol-5-one)-thiazole <b>5,</b>4-methyl-2-yl-amino-(1-N-carboxyl-3,5-dimethyl-<i>1H</i>-pyrazol)-5-(1-N-carboxyl-3,5-dimethyl-<i>1H</i>-pyrazol)-thiazole <b>6, </b>4-methyl-2-yl-amino-(1,3,4-oxadiazolin-5-thione)-5yl-(1,3,4-oxadiazolin-5-thione-2yl)-thiazole <b>7 </b>and 4-methyl-2-yl-amino-(5-substituted-1,3,4-oxadiazol-2yl)-5-(5-substituted-1,3,4-oxadiazol-2yl)-thiazole <b>8a-d, </b>respectively. All the synthesized compounds have been screened for their antimicrobial activity.
Description: 1274-1278
URI: http://hdl.handle.net/123456789/6044
Appears in Collections:IJC-B Vol.48B(09) [September 2009]

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