Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6013
Title: The selectivity of nucleobases in DNA binding by Ru(phenanthroline)<sub>3 </sub>complex
Authors: Hazarika, P
Bezbaruah, B
Gogoi, A
Das, P
Medhi, O K
Medhi, C
Keywords: Coordination chemistry
Theoretical chemistry
<i style="">Ab initio</i> calculations
DNA binding
Sequence specificity
Nucleobases
Ruthenium
Guanine
Adenine
Cytosine
Thymine
Issue Date: Sep-2009
Publisher: CSIR
Series/Report no.: Int. Cl.<sup>9</sup> C07F15/00
Abstract: Interaction ability of Ru(phenanthroline)<sub>3</sub> with various sites of nucleobases like guanine, adenine, cytosine and thymine has been investigated by <i style="">ab initio</i> quantum mechanical calculations. While the N7 of guanine is found to be a susceptible site for binding with Ru metal, the other sites of nucleobases can also bind with this metal centre. The O6 of guanine and O2 of cytosine can form more stable Ru coordinated complexes than N7 of guanine. Formation of bridged hydrogen bonds between polarized atomic sites of this complex and all the nucleobases (except thymine) has been observed. Such hydrogen bonds may also stabilize the complex better than the direct Ru coordinated complexes inside DNA.
Description: 1235-1241
URI: http://hdl.handle.net/123456789/6013
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.48A(09) [September 2009]

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