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Title: Synthesis and characterisation of oxomolybdenum(V) and dioxomolybdenum(VI) complexes with Schiff base derived from isonicotinoylhydrazide
Authors: Nair, M L Harikumaran
Thankaman, D
Keywords: Coordination chemistry;Molybdenum;Schiff bases;Anticancer activity;Antibacterial activity
Issue Date: Sep-2009
Publisher: CSIR
IPC Code: Int. Cl.9 C07C251/02; C07F11/00
Abstract: Synthesis of some new oxomolybdenum(V) and dioxomolybdenum(VI) complexes with a Schiff base, 3-methoxysalicylaldehydeisonicotinoylhydrazone derived from 3-methoxysalicylaldehyde and isonicotinoylhydrazide are reported. The complexes have been characterized by elemental analyses, molar conductance, magnetic susceptibility data, IR, UV-vis, EPR, 1H NMR and FAB mass spectral studies. The physico-chemical studies and spectral data indicate that the ligand acts as a monovalent tridentate chelating agent. The FAB mass and X-band EPR spectra indicate that the pentavalent Mo in the complex [MoO(MSINH)Cl2] is monomeric in nature. The X-ray diffraction studies of [MoO(MSINH)Cl2] correspond to orthorhombic crystal lattice with unit cell dimensions: a = 8.043Ả, b = 12.49Ả and c = 14.936Ả. All the complexes are found to be neutral with distorted octahedral geometry. The thermal properties of the complex [MoO(MSINH)Cl2] have been investigated by thermogravimetric techniques. The ligand, [MoO(MSINH)Cl2] and [MoO2(MSINH)Cl] have been screened for their in vitro anticancer and antibacterial activity. The complex, [MoO(MSINH)Cl2], exhibits much higher activity than the ligand (MSINH) and its dioxocomplex, [MoO2(MSINH)Cl].
Page(s): 1212-1218
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.48A(09) [September 2009]

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