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IJEB Vol.47(09) [September 2009] >


Title: Analgesic and anticonvulsant effects of saponin isolated from the leaves of Clerodendrum infortunatum Linn. in mice
Authors: Pal, Dilipkumar
Sannigrahi, Santanu
Mazumder, Upal Kanti
Keywords: Analgesic and anticonvulsant activity
Aspirin
Clerodendrum infortunatum
Pentazocine
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Saponin (SN1) isolated from C. infortunatum leaves in doses of 30, 50, 75 and 100 mg/kg, ip provided 36.28, 60.47, 90.71, 100% protection respectively from writhing induced by 1.2% v/v acetic acid. In hot plate method, SN1 not only produced analgesia in mice but also potentiated the analgesic action of pentazocine and aspirin. The anticonvulsant activity was tested by leptazol-induced seizures. SN1 decreased the duration of seizures and gave protection in a dose dependent manner against leptazol-induced convulsions. The results suggest that saponin has significant analgesic and anticonvulsant effects.
Page(s): 743-747
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(09) [September 2009]

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