NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(09) [September 2009] >


Title: Antinociceptive property of Emblica officinalis Gaertn (Amla) in high fat diet-fed/low dose streptozotocin induced diabetic neuropathy in rats
Authors: Kumar, N Prem
Annamalai, A R
Thakur, R S
Keywords: Antioxidant
Diabetic neuropathy
Emblica officinalis
Nociception
Oxidative stress
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Diabetic neuropathic pain is an important microvascular complication in diabetes mellitus and oxidative stress plays a vital role in associated neural and vascular complications. The present study investigated flavonoid rich fruit extract (ethyl acetate:methanol fraction) of E.officinalis (10 mg/kg), in type II diabetes (high fat diet fed/low dose streptozotocin) induced diabetic neuropathy in male Sprague-Dawley rats. Diabetic rats exhibited a significant hyperalgesia (nociception) as compared to control rats. Treatment with E.officinalis extract (EOE) and quercetin in diabetic rats showed significant increase in tail flick latency in hot immersion test and pain threshold level in hot plate test compared to control rats. The changes in lipid peroxidation status and anti-oxidant enzymes (superoxide dismutase and catalase) levels observed in diabetic rats were significantly restored by E.officinalis extract and quercetin treatment. Both, E.officinalis extract and quercetin attenuated diabetic induced axonal degeneration. The study provides experimental evidence of the preventive and curative effect of E.officinalis on nerve function and oxidative stress in animal model of diabetic neuropathy. Since, E.officinalis fruit is already in clinical use for diabetic patients it may be evaluated for preventive therapy in diabetic patients at risk of developing neuropathy.
Page(s): 737-742
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(09) [September 2009]

Files in This Item:

File Description SizeFormat
IJEB 47(9) 737-742.pdf96.54 kBAdobe PDFView/Open
 Current Page Visits: 997 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 644562 since 06-Feb-2009  Last updated on 26-Dec-2014Webmaster: nopr@niscair.res.in