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Title: Protective effects of different antioxidants against endosulfan-induced oxidative stress and immunotoxicity in albino rats
Authors: Pal, Rishi
Ahmed, Tanzeel
Kumar, Vivek
Suke, Sanvidhan G
Ray, Arunabha
Banerjee, B D
Keywords: Attenuation;-tocopherol;Immunotoxicity;L-ascorbic acid;N-acetylcystein;Oxidative Stress
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Endosulfan exposure (8 and 16mg/kg) to rats significantly decreased the activities of superoxide dismutase and catalase, level of reduced glutathione and increased lipid peroxidation. The primary and secondary antiSRBC antibody titers, plaque forming cells counts and delayed hypersensivity reaction, and the TH1 or TH2 cytokines levels were significantly suppressed in a dose dependent manner. L-ascorbic acid and -tocopherol produced a synergistic reversal of oxidative stress parameters following endosulfan exposure. N-acetylcysteine produced significant reversal of altered oxidative stress parameters and immune response after endosulfan exposure. A significant attenuation of the oxidative stress markers and immunotoxicity with a combined therapy of L-ascorbic acid plus -tocopherol and with N-acetylcysteine was clearly demonstrated by the present results.
Page(s): 723-729
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.47(09) [September 2009]

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