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Title: Particulate antigen induced immune activation influences steroidogenesis in murine lymphoid organs with parallel increase in circulating IL-6
Authors: Mukhopadhyay, Rupanjan
Bishayi, Biswadev
Keywords: Corticosterone
Lymphoid organ
Particulate antigen
Steroidogenic enzyme
Issue Date: Sep-2009
Publisher: CSIR
Abstract: The effect of sheep red blood cells (SRBC), live Escherichia coli cells administration and interleukin-6 (IL-6) treatment on steroidogenesis in murine lymphoid organs with concomitant changes in serum IL-6 levels were studied in the male Swiss albino mice. From the lymphoid tissue homogenate, the activities of 3βHSD, 17βHSD, corticosterone, testosterone and IL-6 levels of serum were estimated. The 3βHSD activity in murine lymphoid organs, as well as the IL-6 levels in serum increased after administration of SRBC and live E. coli cells, as compared to control. Whereas the 17βHSD activity was decreased in the murine lymphoid organs with a concomitant reduced serum testosterone level was found after particulate antigen administration or IL-6 treatment. The serum corticosterone and serum IL-6 level were also elevated.
Page(s): 699-705
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(09) [September 2009]

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