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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(09) [September 2009] >
| Title: | Particulate antigen induced immune activation influences steroidogenesis in murine lymphoid organs with parallel increase in circulating IL-6 |
| Authors: | Mukhopadhyay, Rupanjan
Bishayi, Biswadev |
| Keywords: | Corticosterone
Cytokine
Lymphoid organ
Particulate antigen
Steroidogenic enzyme |
| Issue Date: | Sep-2009 |
| Publisher: | CSIR |
| Abstract: | The effect of sheep red blood cells (SRBC), live Escherichia coli cells administration and interleukin-6 (IL-6) treatment on steroidogenesis in murine lymphoid organs with concomitant changes in serum IL-6 levels were studied in the male Swiss albino mice. From the lymphoid tissue homogenate, the activities of 3βHSD, 17βHSD, corticosterone, testosterone and IL-6 levels of serum were estimated. The 3βHSD activity in murine lymphoid organs, as well as the IL-6 levels in serum increased after administration of SRBC and live E. coli cells, as compared to control. Whereas the 17βHSD activity was decreased in the murine lymphoid organs with a concomitant reduced serum testosterone level was found after particulate antigen administration or IL-6 treatment. The serum corticosterone and serum IL-6 level were also elevated. |
| Page(s): | 699-705 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.47(09) [September 2009]
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