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Title: Reversed phase thin layer chromatography of five co-administered drugs with surfactant modified solvent systems
Authors: Mohammad, Ali
Sharma, Sudhanshu
Bhawani, Showkat Ahmad
Keywords: Thin layer chromatography
Diclofenac sodium
Ascorbic acid
Issue Date: Jul-2009
Publisher: CSIR
Abstract: The chromatography of five co-administered drugs i.e. paracetamol, ibuprofen, diclofenac sodium, aspirin and ascorbic acid was performed on various reversed phase layers. The surfactant mediated solvent systems were used with various impregnated silica gel H layers for the chromatography of these five drugs. The various experimental conditions were optimized for the selection of optimum concentration of impregnants. The mutual separation of a mixture of paracetamol, diclofenac sodium and ibuprofen; and paracetamol, aspirin and ascorbic acid are achieved on various impregnated silica gel H layers, using surfactant mediated solvent systems containing n-hexane: 1% CTAB in MeOH: ethyl acetate: acetic acid, (13:1:4:2, v/v) and toluene: 1% CTAB in MeOH: n-propanol: formic acid, (14:1:3:2, v/v) respectively.
Page(s): 344-350
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.16(4) [July 2009]

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