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Title: Kinetic studies of penicillin production during batch and repeated batch in fluidized bed bioreactor with agar immobilized P. chrysogenum cells
Authors: Rani, A Swaroopa
Jetty, Annapurna
Ramakrishna, S V
Keywords: Penicillium chrysogenum;agar;penicillin;batch;repeated batch;fluidized bed reactor
Issue Date: Jul-2004
Publisher: CSIR
IPC Code: Int. Cl.7 A 01 N 63/00; C 12 P 37/00
Abstract: The fermentation kinetics of penicillin production by Penicillium chrysogenum was carried out at 27°C and pH 6.0. Batch and repeated batch fermentations using agar-immobilized cells in fluidized bed bioreactor were studied for their potential application in production of penicillin from lactose, a fermentable sugar. Kinetics of immobilized cell fermentation, showed the penicillin yield of ~0.0155 g/l, with highest penicillin concentration of ~57.09 mg/l and the high reactor productivity of ~23.8 mg/l h-1. Repeated batch fermentation experiments showed that the immobilized biocatalysts could be recycled effectively for 5 cycles. Penicillin yield was 4-5-fold greater by this method of immobilization, with high productivity as compared to free cells and other immobilization methods.
Page(s): 394-399
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.03(3) [July 2004]

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