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Title: New Mn(II)-coordination polymer based on flexible benzimidazol ligand: Crystal
Authors: Ni, Zhiming
Ding, Shuchen
Qu, Yuan
Yu, Hongbo
Xia, Junjie
Keywords: Coordination polymer;Osteosarcoma;RT-PCR
Issue Date: Dec-2021
Publisher: NIScPR-CSIR, India
Abstract: In this study, a Mn(II)-based coordination polymer with the chemical composition of {[Mn(L)(TBTA)(H2O)2]ꞏH2O}n (1) has been prepared by reacting Mn(OAc)2ꞏ2H2O with the flexible ligand 1,4-bis(5,6-dimethylbenzimidazol-1-yl)-2-butylene in the aid of the carboxylic acid ligand tetrabromoterephthalic acid (H2TBTA) through the mixed-ligand method. Its application value on osteosarcoma has been measured, and the internal principle is discussed simultaneously. The inhibitory activity of the new compound on the multiplication of osteosarcoma cells is evaluated using the Cell Counting Kit-8 detection kit. The facilitation of the LKB1-mTORC1 signalling pathway is estimated via real-time RT-PCR.
Page(s): 1551-1556
ISSN: 0975-1017 (Online); 0971-4588 (Print)
Appears in Collections:IJC-A Vol.60A(12) [December 2021]

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