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Title: Benzothiazole derivatives of thiazole/ oxazole as potent antimicrobial agents
Authors: Kumar, Gajendra
Keywords: Antimicrobial;miconazole;imipenem;benzothiazole;oxazole;thiazole
Issue Date: Dec-2021
Publisher: NIScPR-CSIR, India
Abstract: Non-steroid biologically active heterocyclic compounds (Z)-N'-(4-(2-(4-chlorophenyl)benzo[d]thiazol-3(2H)-yl) oxazol-2yl)-N-(4-substituted phenylimino)-3-substituted-2,3-dihydrobenzo[d]oxazole-2-carboxamidine (4a-4h) and (Z)-N'- (4-(2- (4-chlorophenyl)benzo[d]thiazol-3(2H)-yl)thiazol-2-yl)-N- (4-substituted phenylimino) -3-substituted-2-hydrobenzo[d] thiazole-2-carboxamidine (4a’-4h’) have been synthesized, tested for their antimicrobial inhibiting potential and compared with standard drugs Miconazole (antifungal) and Imipenem (antibacterial). Compound 4e’ is more potentially active than other compounds and standard drugs. The structure configuration of newly synthesized compounds has been determined by elemental analysis and various spectroscopic (IR, 1H and 13CNMR and GCMS) techniques.
Page(s): 1607-1620
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(12) [December 2021]

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