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Title: Synthesis, antioxidant and antibacterial activities of quinoline incorporated 2,4,5trisubstituted imidazole derivatives
Authors: Somashekara, B
Vijayakumar, G R
Keywords: 2-Chloroquinoline;2-hydroxyquinoline;antioxidant;antibacterial
Issue Date: Dec-2021
Publisher: NIScPR-CSIR, India
Abstract: A series of quinoline incorporated 2,4,5-trisubstituted imidazole derivatives (4a-h and 5a-f) have been synthesized. The structures of the synthesized compounds have been established by FT-IR, 1H NMR and mass spectral analysis. The prepared compounds have been evaluated for their in vitro antioxidant activity by DPPH method and antibacterial activity against Bacillus subtilis, Escherichia coli, Bacillus megaterium and Salmonella typhi bacterial strains at 500 µg/mL concentration. The compounds 4a, 4e and 4d exhibit good antioxidant activity. Among the synthesized compounds, 4a has shown significant antibacterial activity against all the three tested microorganisms.
Page(s): 1601-1606
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(12) [December 2021]

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