Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/58496
Title: Quantitative estimation and evaluation of anti-inflammatory activity of macromolecules of Boswellia serrata
Authors: V, Sampath
Mukhopadhyay, Nabarun
Pai, Sameer
N, Dilip
M, Sai Sandeep
Babu, U V
Lobo, Richard
Pai, Vasudev
Keywords: Anti-inflammatory activity;Boswellia serrata;IL-6 ELISA;Macromolecules;MTT assay
Issue Date: Oct-2021
Publisher: CSIR-NIScPR
IPC Code: Int Cl.21: A61K 9/00, A61K 36/00, A61K 36/185, A61K 36/324, A61K 39/395, A61K 45/06
Abstract: The present study was aimed to isolate and perform qualitative analysis of macromolecules present in Boswellia serrata followed by evaluation of their anti-inflammatory activity by in-vitro IL-6 ELISA study. The oleo gum resin of B. serrata was pretreated with hexane, methanol and the obtained residue was extracted with water and the final dried powder was taken for macromolecule analysis. The macromolecules which comprise of polysaccharides, mucilages and proteins were quantitatively estimated and evaluated for their anti-inflammatory activity by in-vitro IL-6 ELISA study. From the current study, it was found that the macromolecules present in B. serrata majorly comprise of polysaccharides and mucilages with moderate quantity of proteins. The quantitative analysis of polysaccharides, mucilages and proteins were found 35.91%, 34% and 14.29%. From the in-vitro IL-6 ELISA study, it was found that the macromolecules showed 82.63% inhibition of IL-6. The identified macromolecules from B. serrata showed significant anti-inflammatory activity by inhibition of IL- 6 and further need to confirm by in vivo study to qualify B. serrata macromolecules as a promising anti-inflammatory agent.
Page(s): 940-943
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.20(4) [October 2021]

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