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Title: An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst
Authors: Safarzaei, Mohyeddin
Mollashahi, Ebrahim
Lashkari, Mojtaba
Maghsoodlou, Malek Taher
Hazeri, Nourallah
Keywords: Lactic acid;6-amino-1;3-dimethyluracil;aryl aldehyde;malononitrile;solvent-free conditions
Issue Date: Oct-2021
Publisher: NIScPR-CSIR, India
Abstract: An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90°C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology and easy workup.
Page(s): 1368-1372
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(10) [October 2021]

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