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Title: A convenient metal free approach towards the synthesis of dihydropyrimidones mediated by achiral nicotinic acid without solvent
Authors: Imon, Mohinuddin Khan
Kamma, Koteswara R
Islam, M N
Roy, Harendra N
Keywords: Dihydropyrimidones;nicotinic acid;solvent-free;N-heterocycles;metal-free
Issue Date: Oct-2021
Publisher: NIScPR-CSIR, India
Abstract: A very simple arrangement of Biginelli’s condensation reaction of 1,3-dicarbonyl compound, aromatic / aliphatic aldehyde and urea / thiourea has been performed in a convenient way by using nicotinic acid without any solvent and under ambient conditions. This approach of pyrimidone synthesis is simple, versatile, metal-free, high yielding and environmentally benign.
Page(s): 1378-1384
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(10) [October 2021]

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