Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/58198
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dc.contributor.authorRathod, Shrimant V-
dc.contributor.authorShinde, Kailas W-
dc.contributor.authorKharkar, Prashant S-
dc.contributor.authorShah, Chetan P-
dc.contributor.authorAruna, K-
dc.contributor.authorRaut, Darshana A-
dc.date.accessioned2021-09-29T10:43:59Z-
dc.date.available2021-09-29T10:43:59Z-
dc.date.issued2021-09-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/58198-
dc.description1215-1222en_US
dc.description.abstractA new class of quinoline analogues have been synthesized from isatin through two steps in good yields. They have been further evaluated for their anticancer activity against a breast cancer cell line (MDA-MB-231) and antibacterial activity against Gram-positive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). All synthesized compounds have been confirmed by spectral characterization viz. FT-IR, MS, HPLC, 1H and 13C NMR. Among them, compound 4h exhibits promising anti-breast cancer activity whereas compounds 4d, 4f, 4h and 4j exhibit moderate antibacterial activity against all the tested organisms. Molecular docking analysis demonstrates the interaction of compound 4h with the active site amino acid of Human Carbonic Anhydrase I, Protein Kinase A and Kinesin Spindle Protein (KSP).en_US
dc.language.isoenen_US
dc.publisherNIScPR-CSIR, Indiaen_US
dc.sourceIJC-B Vol.60B(09) [September 2021]en_US
dc.subjectAntibacterialen_US
dc.subjectanticanceren_US
dc.subjectdockingen_US
dc.subjectMDA-MB-231en_US
dc.subjectquinoline analoguesen_US
dc.subjectsynthesisen_US
dc.titleSynthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agentsen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.60B(09) [September 2021]

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