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Title: Preparation, characterization, antibacterial, antifungal and antioxidant activities of novel pyrazole-thiazole derivatives
Authors: Shah, Purvesh J
Keywords: Pyrazole-thiazole;spectral studies;antimicrobial activity;antioxidant activity
Issue Date: Sep-2021
Publisher: NIScPR-CSIR, India
Abstract: In the present study, 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)-N-(2,3-diphenyl-5-aryl-3,3a-dihydro-2H-pyrazolo [3,4-d]thiazol-6(5H)-yl)benzamide IVa-h has been synthesized by reaction between various 4-((1H-benzo[d][1,2,3]triazol- 1-yl) methylamino)-N-(5-arylidene-4-oxo-2-phenylthiazolidin-3-yl)benzamides IIa-h with phenyl hydrazine. The reaction of 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)-N-(4-oxo-2-aryl thiazolidin -3-yl) benzamide Ia-h with benzaldehyde yields IIa-h. All the newly prepared compounds have been characterized by various spectroscopic techniques and screened for their in vitro antimicrobial and antioxidant activity. The investigation of anti microbial screening data reveals that most of the compounds tested have demonstrated moderate to good activity. Most of the heterocyclic derivatives bearing two hydroxyl groups on the phenyl ring show excellent antioxidant activity in comparison with ascorbic acid.
Page(s): 1223-1229
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(09) [September 2021]

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