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Title: Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water
Authors: Thiyam, Medhabati
Thaodem, Ranjana Devi
Laitonjam, Warjeet Singh
Keywords: Synthesis;arylbenzo[4,5]thiazolopyrimido[5,4-d]pyrimidin-4-ones;metal-proline;aqueous medium
Issue Date: Sep-2021
Publisher: NIScPR-CSIR, India
Abstract: A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach.
Page(s): 1230-1242
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(09) [September 2021]

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IJC (Section B), 60B, 1230-1242 (Sep,2021).pdfMain Article1.04 MBAdobe PDFView/Open
IJC (Section B), 60B, 1230-1242 (Sep,2021) Suppl. Data.pdfSupplementary Data794.95 kBAdobe PDFView/Open

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