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Title: Synthesis and biological activity of 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one
Authors: Bhirud, Jayashri D
More, Yogesh B
Baviskar, Pankaj D
Narkhede, Hemant P
Keywords: Coumarin triazole;anti-bacterial;anti-fungal activities;solvent/base pair
Issue Date: Aug-2021
Publisher: NIScPR-CSIR, India
Abstract: Incorporation of other hetero-compounds to parent coumarin increases its effectiveness towards its bioactivity. In view of this finding we have synthesized coumarin triazole derivatives. The key synthon used for this reaction pathway are 7-hydroxy-4-methyl-2H-chromen-2-one. This substituted coumarin has been refluxed with 1-bromo-2-chloroethane in presence ofanhydrous K2CO3 to afford 7-(2-chloroethoxy)-4-methyl-2H-chromen-2-one, which has been condensed with triazole to yield4-methyl coumarin triazole derivative by optimising solvent/base pair. 4-Methyl group of coumarin triazole derivative has beencondensed with aromatic aldehydes to afford 7-(2-(1H-1,2,4-triazol-1-yl) ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one 7a-e. All the synthesized products are characterized using IR and, 1H, 13C NMR, mass spectroscopy and elemental analysis.Final synthesized compounds 7a-e have been evaluated for their anti-bacterial and anti-fungal activity.
Page(s): 1197-1102
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(08) [August 2021]

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