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|Title:||An efficient synthesis of Vildagliptin intermediates|
|Keywords:||Vildagliptin;intermediate;3-amino-1-adamantane alcohol;(S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile|
|Abstract:||Efficient and high yielding methods for the preparation of vildagliptin 1 intermediate of (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile 2 and 3-amino-1-adamantane alcohol 3 respectively have been described. (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 2 has been synthesized from L-proline 2a via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot reactions. 3-Amino-1-adamantane alcohol 3 has been prepared from amantadine hydrochloride via oxidation by sulfuric acid/nitric acid and boric acid as catalyst, and has been subjected to ethanol extraction. The overall yield is about 95%.|
|Appears in Collections:||IJC-B Vol.60B(08) [August 2021]|
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|IJC (Section B), 60B, 1128-1131 (Aug,2021).pdf||230.39 kB||Adobe PDF||View/Open|
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