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Title: Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities
Authors: Lagdhir, Mohit
Pandya, Chintan
Pandya, Aditee
Vekariya, Rajesh H
Rajani, Dhanji P
Keywords: Molecular hybridization;pharmacophore;quinoline;structural activity relationship (SAR);antimicrobial activity;antimalarial activity;antitubercular activity
Issue Date: Jul-2021
Publisher: NIScPR-CSIR, India
Abstract: All the molecules have been designed on the basis of previously reported active pharmacophores via molecular hybridization. A convenient protocol for the preparation of N-((2-(piperazin-1-yl) quinolin-3-yl)methyl)aniline derivatives via mutli-step synthesis has been described. Spectral analysis using Mass, 1H and 13C NMR spectral techniques have been studied in order to confirm the structure of synthesized end molecules. All synthesized compounds have been screened for in vitro antimicrobial, antimalarial and antitubercular activities. Structural activity relationship study (SAR) have also been discussed. Interestingly, target molecules are found to show good to excellent antibacterial, antifungal and antimalarial potency.
Page(s): 986-998
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(07) [July 2021]

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