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Title: Synthesis of isomeric naphthofuranyl coumarins as anti-inflammatory and analgesic agents
Authors: Yaragatti, Naazneen
Khanapurmath, Netravati
Kulkarni, Manohar V
Keywords: Naphthofuranyl;coumarin;anti-inflammatory;analgesic activity;angular/linear naphthofuranyl coumarins
Issue Date: Jul-2021
Publisher: NIScPR-CSIR, India
Abstract: A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins have been found to exhibit anti-inflammatory activity comparable to asprin but when tested for analgesic activity, angularly fused naphthofuranyl coumarins show better activity comparable to asprin whereas linear naphthofuranyl coumarins are less active.
Page(s): 1007-1013
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(07) [July 2021]

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IJC (Section B), 60B, 1007-1013 (Jul,2021).pdfMain Article473.81 kBAdobe PDFView/Open
IJC (Section B), 60B, 1007-1013 (Jul,2021) Suppl. Data.pdfSupplementary Data595.35 kBAdobe PDFView/Open

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