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Title: Serum biochemical markers in rheumatoid arthritis
Authors: Pallinti, Vasanthi
Ganesan, Nalini
Anbazhagan, M
Rajasekhar, G
Keywords: Homocysteine
Adenosine deaminase
Oxidative stress
Rheumatoid arthritis
Issue Date: Aug-2009
Publisher: CSIR
Abstract:  Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis. In the present study, homocysteine, cortisol, adenosine deaminase (ADA), ferritin, malondialdehyde (MDA) and -tocopherol in serum of RA patients and healthy individuals were estimated to assess if they contribute to the disease process. The markers of disease activity such as erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) were also measured. The study group included a total of 45 subjects, including 30 RA patients and the rest being healthy individuals. RA group showed a significant increase in the levels of homocysteine, ADA and MDA, and a significant decrease in α-tocopherol compared to the healthy individuals. However, cortisol and ferritin levels did not show any significant change. Also, there was no significant correlation between the studied serum markers and markers of disease activity. Our results indicate that these biochemical markers contribute independently to the pathogenesis of RA.
Page(s): 342-344
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.46(4) [August 2009]

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