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Title: Biocatalytic acylation of Efavirenz intermediate: Unexpected novel product formation
Authors: Husain, Mofazzal
Lahiri, Saswata
Tomar, Shilpi
Parmar, Virinder S
Datta, Debashish
Keywords: Biocatalytic acylation;Efavirenz;benzoxazine derivative;lipase B
Issue Date: Aug-2009
Publisher: CSIR
Abstract: During attempted biocatalytic resolution of (R/S)-5-chloro--(cyclopropylethynyl)-2-amino--(trifluoromethyl) benzenemetha­nol containing a tertiary hydroxyl group, a novel, unexpected benzoxazine derivative (Efavirenz analogue) is formed during the lipase B from Candida antarctica (Novozyme -435) catalyzed reaction of Efavirenz intermediate (R/S)-5-chloro--(cyclo­pro­pylethynyl)-2-amino--(trifluoromethyl) benzenemethanol 1 using vinyl acetate.
Page(s): 1174-1177
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(08) [August 2009]

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