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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(08) [August 2009] >
| Title: | Biocatalytic acylation of Efavirenz intermediate: Unexpected novel product formation |
| Authors: | Husain, Mofazzal
Lahiri, Saswata
Tomar, Shilpi
Parmar, Virinder S
Datta, Debashish |
| Keywords: | Biocatalytic acylation
Efavirenz
benzoxazine derivative
lipase B |
| Issue Date: | Aug-2009 |
| Publisher: | CSIR |
| Abstract: | During attempted biocatalytic resolution of (R/S)-5-chloro- -(cyclopropylethynyl)-2-amino--(trifluoromethyl) benzenemethanol containing a tertiary hydroxyl group, a novel, unexpected benzoxazine derivative (Efavirenz analogue) is formed during the lipase B from Candida antarctica (Novozyme -435) catalyzed reaction of Efavirenz intermediate (R/S)-5-chloro--(cyclopropylethynyl)-2-amino--(trifluoromethyl) benzenemethanol 1 using vinyl acetate. |
| Page(s): | 1174-1177 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(08) [August 2009]
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