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Title: Biocatalytic acylation of Efavirenz intermediate: Unexpected novel product formation
Authors: Husain, Mofazzal
Lahiri, Saswata
Tomar, Shilpi
Parmar, Virinder S
Datta, Debashish
Keywords: Biocatalytic acylation
benzoxazine derivative
lipase B
Issue Date: Aug-2009
Publisher: CSIR
Abstract: During attempted biocatalytic resolution of (<i style="">R</i>/<i style="">S</i>)-5-chloro-<img src='/image/spc_char/alpha.gif'>-(cyclopropylethynyl)-2-amino-<img src='/image/spc_char/alpha.gif'>-(trifluoromethyl) benzenemetha­nol containing a tertiary hydroxyl group, a novel, unexpected benzoxazine derivative (Efavirenz analogue) is formed during the lipase B from <i style="">Candida antarctica</i> (Novozyme -435) catalyzed reaction of Efavirenz intermediate (<i style="">R</i>/<i style="">S</i>)-5-chloro-<img src='/image/spc_char/alpha.gif'>-(cyclo­pro­pylethynyl)-2-amino-<img src='/image/spc_char/alpha.gif'>-(trifluoromethyl) benzenemethanol <b style="">1</b> using vinyl acetate.
Description: 1174-1177
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(08) [August 2009]

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