NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(08) [August 2009] >


Title: Synthesis of biologically active novel bis Schiff bases, bis hydrazone and bis guanidine derivatives
Authors: Sondhi, Sham M
Dinodia, Monica
Jain, Shubhi
Kumar, Ashok
Keywords: Schiff base
hydrazone
guanidine
anti-inflammatory
analgesic
Issue Date: Aug-2009
Publisher: CSIR
Abstract: A number of bis Schiff′s bases 3a-d have been synthesized by condensation of 2,4,8,10 tetraoxaspiro[5,5]undecane 3,9-dipropanamine 1 with furfural, indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine and 5a-c by condensation of 1,4-bis (3-aminopropyl) piperazine 4 with indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine, in high yields by using microwave irradiation. Bis hydrazone derivatives 8a-c are obtained by condensation of 2,6-diacetylpyridine 7 with various arylsulfonylhydrazides using microwave irradiation. A number of bis guanidine derivatives 11a-j are synthesized by condensation of 1,3-diaminoguanidine monohydrochloride 10 with various aldehydes 9a-c and ketones 9d-j. The structures assigned to these purified compounds i.e 3a-d, 5a-c, 8a-c, and 11a-j, are supported by correct spectral data and elemental analysis. Anti-inflammatory activities of 3b and 11e are comparable to standard drug phenyl butazone. Analgesic activities of 11e and 3b are compared with phenyl butazone and 3b showed better activity then phenyl butazone.
Page(s): 1128-1136
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Source:IJC-B Vol.48B(08) [August 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(8) 1128-1136.pdf184.23 kBAdobe PDFView/Open
 Current Page Visits: 802 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 621498 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in