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Title: An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents
Authors: Gullapelli, Kumaraswamy
Maroju, Ravichandar
Merugu, Ramchander
Keywords: Benzimidazole;Docking study;Isoxazole;Pyrazole;Synthesis
Issue Date: May-2021
Publisher: NIScPR-CSIR, India
Abstract: The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine. The newly synthesised compounds were screened for their in vitro anti-inflammatory activity and demonstrated excellent to moderate activity and molecular docking study reports are supporting anti-inflammatory activity showed high inhibition constant and binding energy. The structures of synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic methods.
Page(s): 343-350
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.28(3) [May 2021]

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