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IJC-B Vol.48B [2009] >
IJC-B Vol.48B(08) [August 2009] >


Title: Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains
Authors: Panda, Gautam
Parai, Maloy Kumar
Srivastava, Ajay Kumar
Chaturvedi, Vinita
Manju, Y K
Sinha, Sudhir
Keywords: Tuberculosis
pyrazinamide
alkylaminoethyl chains
Issue Date: Aug-2009
Publisher: CSIR
Abstract: Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-25 g/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubercular activity. Among heteroaryl containing triarylmethanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.
Page(s): 1121-1127
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Source:IJC-B Vol.48B(08) [August 2009]

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