Please use this identifier to cite or link to this item:
Title: VOSO4-catalyzed Biginelli condensation: An efficient synthesis of dihydro-1H-pyrimidine-2-thione/one and octahydro-2,5-quinazolinedione
Authors: Reddy, Ch Sanjeeva
Raghu, M
Nagaraj, A
Keywords: VOSO4 catalyst;dihydro-1H-pyrimidine-2-thione/one;octahydro-2,5-quinazolinedione;solvent-free;microwave irradiation
Issue Date: Aug-2009
Publisher: CSIR
Abstract:  The three component condensation of an aldehyde 1, urea/thiourea 2 and β-ketoester 3 / dimidone 7 in the presence of a catalytic amount of VOSO4 is disclosed for the synthesis of 3,4-dihydro-1H-pyrimidine-2-thione/one (DHPMs) 4 and octahydro-2,5-quinazolinedione 8 under solvent-free microwave irradiation conditions. High yields are achieved even on 1 g scale, while reaction times are considerably shortened compared to conven­tional heating conditions.
Page(s): 1178-1182
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(08) [August 2009]

Files in This Item:
File Description SizeFormat 
IJCB 48B(8) 1178-1182.pdf139.26 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.