Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5781
Title: VOSO4-catalyzed Biginelli condensation: An efficient synthesis of dihydro-1H-pyrimidine-2-thione/one and octahydro-2,5-quinazolinedione
Authors: Reddy, Ch Sanjeeva
Raghu, M
Nagaraj, A
Keywords: VOSO4 catalyst
dihydro-1H-pyrimidine-2-thione/one
octahydro-2,5-quinazolinedione
solvent-free
microwave irradiation
Issue Date: Aug-2009
Publisher: CSIR
Abstract:  The three component condensation of an aldehyde 1, urea/thiourea 2 and β-ketoester 3 / dimidone 7 in the presence of a catalytic amount of VOSO4 is disclosed for the synthesis of 3,4-dihydro-1H-pyrimidine-2-thione/one (DHPMs) 4 and octahydro-2,5-quinazolinedione 8 under solvent-free microwave irradiation conditions. High yields are achieved even on 1 g scale, while reaction times are considerably shortened compared to conven­tional heating conditions.
Description: 1178-1182
URI: http://hdl.handle.net/123456789/5781
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(08) [August 2009]

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