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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(08) [August 2009] >
| Title: | VOSO4-catalyzed Biginelli condensation: An efficient synthesis of dihydro-1H-pyrimidine-2-thione/one and octahydro-2,5-quinazolinedione |
| Authors: | Reddy, Ch Sanjeeva
Raghu, M
Nagaraj, A |
| Keywords: | VOSO4 catalyst
dihydro-1H-pyrimidine-2-thione/one
octahydro-2,5-quinazolinedione
solvent-free
microwave irradiation |
| Issue Date: | Aug-2009 |
| Publisher: | CSIR |
| Abstract: | The three component condensation of an aldehyde 1, urea/thiourea 2 and β-ketoester 3 / dimidone 7 in the presence of a catalytic amount of VOSO4 is disclosed for the synthesis of 3,4-dihydro-1H-pyrimidine-2-thione/one (DHPMs) 4 and octahydro-2,5-quinazolinedione 8 under solvent-free microwave irradiation conditions. High yields are achieved even on 1 g scale, while reaction times are considerably shortened compared to conventional heating conditions. |
| Page(s): | 1178-1182 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(08) [August 2009]
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