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Title: VOSO<sub>4</sub>-catalyzed Biginelli condensation: An efficient synthesis of dihydro-1<i style="">H</i>-pyrimidine-2-thione/one and octahydro-2,5-quinazolinedione
Authors: Reddy, Ch Sanjeeva
Raghu, M
Nagaraj, A
Keywords: VOSO<sub>4</sub> catalyst
dihydro-1<i style="">H</i>-pyrimidine-2-thione/one
microwave irradiation
Issue Date: Aug-2009
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> The three component condensation of an aldehyde <b style="">1</b>, urea/thiourea <b style="">2</b> and <i style="">β</i>-ketoester <b style="">3</b> / dimidone <b style="">7</b> in the presence of a catalytic amount of VOSO<sub>4</sub> is disclosed for the synthesis of 3,4-dihydro-1<i style="">H</i>-pyrimidine-2-thione/one (DHPMs) <b style="">4</b> and octahydro-2,5-quinazolinedione <b style="">8</b> under solvent-free microwave irradiation conditions. High yields are achieved even on 1 g scale, while reaction times are considerably shortened compared to conven­tional heating conditions. </smarttagtype>
Description: 1178-1182
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Appears in Collections:IJC-B Vol.48B(08) [August 2009]

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