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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(08) [August 2009] >
| Title: | Synthesis and antimicrobial activity of 3-propene 1,2-benzisoxazole derivatives |
| Authors: | Shastri, R A
Varudkar, J S |
| Keywords: | 3-Propene
1,2-benzisoxazole
microwave irradiation
antimicrobial activity |
| Issue Date: | Aug-2009 |
| Publisher: | CSIR |
| Abstract: | A convenient and eco-friendly synthesis of 3-propene 1,2-benzisoxazole derivatives 5a-h has been achieved in excellent yields from the corresponding substituted o-hydroxy acetophenones. Substituted o-hydroxy acetophenones 1a-h on treatment with acetaldehyde 2 in sodium hydroxide afford 1-(2′-hydroxy aryl)-2-butene-1-ones 3a-h. Compounds 3a-h on oximation yields 4a-h. Microwave irradiation of 4a-h on solid support silica gel affords 5a-h in very good yield. The resultant 3-propene 1,2-benzisoxazoles have been characterized by spectral data. The compounds 5a-h have been screened for their antimicrobial activity. Compounds 5b, d, e, g exhibit good antibacterial activity and compounds 5b-e exhibit marked antifungal activity. |
| Page(s): | 1156-1160 |
| ISSN: | 0975-0983 (Online); 0376-4699 (Print) |
| Source: | IJC-B Vol.48B(08) [August 2009]
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