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IJC-B Vol.48B(08) [August 2009] >


Title: Synthesis and antimicrobial activity of 3-propene 1,2-benzisoxazole derivatives
Authors: Shastri, R A
Varudkar, J S
Keywords: 3-Propene
1,2-benzisoxazole
microwave irradiation
antimicrobial activity
Issue Date: Aug-2009
Publisher: CSIR
Abstract:  A convenient and eco-friendly synthesis of 3-propene 1,2-benzisoxazole derivatives 5a-h has been achieved in excellent yields from the corresponding substituted o-hydroxy aceto­phenones. Substituted o-hydroxy acetophenones 1a-h on treat­ment with acetaldehyde 2 in sodium hydroxide afford 1-(2′-hydroxy aryl)-2-butene-1-ones 3a-h. Compounds 3a-h on oximation yields 4a-h. Microwave irradiation of 4a-h on solid support silica gel affords 5a-h in very good yield. The resultant 3-propene 1,2-benzisoxazoles have been characterized by spectral data. The compounds 5a-h have been screened for their antimicrobial activity. Compounds 5b, d, e, g exhibit good antibacterial activity and compounds 5b-e exhibit marked antifungal activity.
Page(s): 1156-1160
ISSN: 0975-0983 (Online); 0376-4699 (Print)
Source:IJC-B Vol.48B(08) [August 2009]

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