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Title: Surface modifications of biodegradable polymeric nanoparticles and their characterization by advanced electron microscopy techniques
Authors: Kulshrestha, Ritu
Singh, Amit
Kumar, Pawan
Mishra, AK
Dinda, AK
Keywords: Electron microscopic characteristics;Polymeric nanoparticles;Surface modifications
Issue Date: Aug-2021
Publisher: NIScPR-CSIR, India
Abstract: Polymeric nanoparticles have been the focus for nanocarrier preparation in numerous biomedical applications such as cancer treatment, disease diagnosis, vaccination, in the last two decades. They have been variably surface modified using copolymers, Polyethylene glycol (PEG), dextran, cyclodextrin, cytokines, small molecules to improve their efficiency and efficacy. The resulting nano-formulations include polymer-protein conjugate, polymeric micelle, polymer-small molecule conjugate, dendrimer, polymeric vesicles, nano-hybrids, hydrogels etc. These may have intrinsic immunogenicity and require accurate characterization in order to improve their pharmacological targeting, pharmacokinetic profiles and to reduce adverse reactions. Therefore, we have reviewed the polymeric nanoparticles and the electron microscopy techniques available for their characterization in the context of their surface modifications and functionalization.
Page(s): 321-333
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.58(4) [August 2021]

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