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Title: Chemical composition, antimicrobial, and antioxidant activities of the essential oils from stem, leaves, and seeds of Caryopteris foetida (D. don) Thell.
Authors: Joshi, Archana
Pant, A K
Prakash, Om
Kumar, Ravendra
Stocki, Marcin
Isidorov, Valery A
Keywords: Anti-inflammatory;Antioxidant;BHT;Caryopteris foetida;δ-cadinene
Issue Date: Jun-2021
Publisher: NIScPR-CSIR, India
IPC Code: Int. cl. (2015.01)- A61K 36/00, A61K 36/85, A61K 127/00, A61K 131/00, A61K 135/00, A61P 39/00, A61P 31/00
Abstract: Caryopteris foetida (D. Don) Thell. also known as stinking blue beard is an aromatic shrub of family verbenaceae. The essential oils from the leaf, stem, and seeds of C. foetida were extracted and analyzed in search of a novel compound. Over 73 constituents were identified from the essential oils of leaf, seeds, and stem. The major compound identified in the leaf oil was δ-cadinene (15.4%) followed by β-caryophyllene (7.8%), (E)-β-farnesene (8.3%), γ-cadinene (7.5%), spathulenol (7.2%), and τ-muurolol (5.1%). The stem oil predominantly consisted of methyl 7-methylcyclopenta[c]pyran-4-carboxylate (15.8%) along with a significant amount of δ-cadinene (11.6%) and γ-cadinene (5.6%), whereas seed oil was characterized by the presence of β-caryophyllene (14.3%) along with α-humulene (8.6%) and β-bisabolene (9.4%). The essential oils were screened for their in vitro antioxidant potential in terms of radical scavenging, metal chelating and reducing assay. The leaf oil exhibited strong DPPH radical scavenging (IC50 =5.1±0.2 μg/mL) and reducing activity (IC50 =3.6±0.5 μg/mL). The antibacterial potential was tested against Salmonela typhimurium, Escherichia coli, Staphylococcus Aureus, and Bacillus megaterium. Maximum activity was exhibited by the essential oils from the leaf and seed. The essential oils were also analyzed for their in vitro anti-inflammatory activity by the protein denaturation method. Both the leaf and stem essential oils exhibited good anti-inflammatory activity with IC50 value of 12.8±0.0 μg/mL and 17.3±0.0 μg/mL respectively.
Page(s): 214-224
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.12(2) [June 2021]

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