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Title: Design, synthesis and antibacterial activity of 9-aryl-6-(2-naphthyl) [1,2,4]triazolo[4,3-a][1,8]naphthyridines
Authors: Challa, Pradeep Kumar
Ega, Jagadeesh Kumar
Siddoju, Kavitha
Keywords: 1,8-Naphthyridine;1,2,4-triazole;SiO2-FeCl3;microwave irradiation;antibacterial activity
Issue Date: Jun-2021
Publisher: NIScPR-CSIR, India
Abstract: A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4] triazolo[4,3-a][1,8]naphthyridines8 by the oxidation of the corresponding aryl aldehyde1-[3-(2-naphthyl) [1,8]naphthyridin- 2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave irradiation. The desired products are obtained in very good yields and in a state of high purity. The structure of compounds 3-8 have been confirmed by their spectroscopic (IR, 1H NMR and MS) and analytical data. The compounds 8a-j have been screened for their antibacterial activity
Page(s): 901-905
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(06) [June 2021]

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