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Title: Dibenzofurans from Cladonia corniculata Ahti and Kashiw inhibit key enzymes involved in inflammation and gout: An in vitro approach
Authors: Tatipamula, Vamsi Krishna
Tatipamula, Vinay Bharadwaj
Keywords: 5-Lipoxygenase;Cladonia corniculata;Cyclooxygenase;Lichen;Xanthine oxidase
Issue Date: May-2021
Publisher: NISCAIR-CSIR, India
Abstract: The usage of natural sources like lichen extracts and their metabolites as anti-inflammatory agents is well known for ages. Based on the data of the folklore and documented books, researchers tested lichens and their products for anti-inflammatory properties and they identified many therapeutic agents used to diagnosis acute and chronic inflammation with lesser side effects. In this study, we aimed to examine the acetone extract of Cladonia corniculata(AE)and its metabolites for in vitro anti-inflammatory and anti-gout effects. Through chemical investigation, we have successfully isolated and identified three known dibenzofurans, namely alectosarmentin 1, porphyrilic acid 2, and strepsilin 3 from the AE. All isolated dibenzofurans1-3 showed prominent inhibition of cyclooxygenase enzymes, whereas compounds 1 and 2 exhibited noticeable inhibition of 5-lipoxygenase enzyme. Only compound 2 showed significant inhibition of xanthine oxidase enzyme with an IC50 value of 80.17±0.66 µg/mL, while standard drug allopurinol with 9.10±0.64 µg/mL. The results indicate that C. corniculatacan be a favourable natural source for the treatment of inflammation and gout and these actions are linked to the natural active dibenzofurans1-3.
Page(s): 715-719
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(05) [May 2021]

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