Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5756
Title: RNA Interference: A revolution in drug development
Authors: Gairola, Neha
Joshi, Sonali N
Dhaneshwar, Suneela S
Keywords: antisense technology
RNA interference (RNAi)
gene silencing
short interfering RNAs (siRNA)
Issue Date: Jul-2005
Publisher: CSIR
Series/Report no.: Int. Cl.<sup>7</sup> A61K31/713; 48/00
Abstract: RNA interference (RNAi) or gene silencing technology is a phenomenon by which double stranded RNAs elicit degradation of a target mRNA containing homologous sequence. It is essentially a new incarnation of well-established antisense principle. This technology enables the researchers to trigger post-transcriptional gene silencing <i style="">in vivo</i>. It<i style=""> </i>is<i style=""> </i>a robust method for lowering specific protein levels, compared to traditional techniques such as antisense, ribozymes or microinjection of function-blocking antibodies. RNAi offers a powerful tool for ascribing functions to genes while its application to <i style="">in vivo</i> models of disease opens up tremendous opportunities to develop a novel generation of oligonucleotide-based drugs, thus offering an enormous potential of being developed as a therapeutic modality.
Description: 316-322
URI: http://hdl.handle.net/123456789/5756
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.04(3) [July 2005]

Files in This Item:
File Description SizeFormat 
IJBT 4(3) 316-322.pdf108.08 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.