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Title: RNA Interference: A revolution in drug development
Authors: Gairola, Neha
Joshi, Sonali N
Dhaneshwar, Suneela S
Keywords: antisense technology;RNA interference (RNAi);gene silencing;short interfering RNAs (siRNA)
Issue Date: Jul-2005
Publisher: CSIR
IPC Code: Int. Cl.7 A61K31/713; 48/00
Abstract: RNA interference (RNAi) or gene silencing technology is a phenomenon by which double stranded RNAs elicit degradation of a target mRNA containing homologous sequence. It is essentially a new incarnation of well-established antisense principle. This technology enables the researchers to trigger post-transcriptional gene silencing in vivo. It is a robust method for lowering specific protein levels, compared to traditional techniques such as antisense, ribozymes or microinjection of function-blocking antibodies. RNAi offers a powerful tool for ascribing functions to genes while its application to in vivo models of disease opens up tremendous opportunities to develop a novel generation of oligonucleotide-based drugs, thus offering an enormous potential of being developed as a therapeutic modality.
Page(s): 316-322
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.04(3) [July 2005]

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