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Indian Journal of Biotechnology (IJBT) >
IJBT Vol.04 [2005] >
IJBT Vol.04(3) [July 2005] >
| Title: | RNA Interference: A revolution in drug development |
| Authors: | Gairola, Neha
Joshi, Sonali N
Dhaneshwar, Suneela S |
| Keywords: | antisense technology
RNA interference (RNAi)
gene silencing
short interfering RNAs (siRNA) |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.7 A61K31/713; 48/00 |
| Abstract: | RNA interference (RNAi) or gene silencing technology is a phenomenon by which double stranded RNAs elicit degradation of a target mRNA containing homologous sequence. It is essentially a new incarnation of well-established antisense principle. This technology enables the researchers to trigger post-transcriptional gene silencing in vivo. It is a robust method for lowering specific protein levels, compared to traditional techniques such as antisense, ribozymes or microinjection of function-blocking antibodies. RNAi offers a powerful tool for ascribing functions to genes while its application to in vivo models of disease opens up tremendous opportunities to develop a novel generation of oligonucleotide-based drugs, thus offering an enormous potential of being developed as a therapeutic modality. |
| Page(s): | 316-322 |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.04(3) [July 2005]
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