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Title: Shigellocidal activity of some medicinal plants used in folklore remedies by tribals of Mahakoshal region of Central India
Authors: Sharma, Anjana
Patel, Virendra Kumar
Ramteke, Padmini
Keywords: Medicinal plants
<i>Saraca asoca </i>(Roxb.) De Wilde
<i>Bacopa</i><i> monnieri </i>(Linn.) Penn.
<i>Zingiber</i><i> officinale </i>Rosc.
<i>Terminalia</i><i> chebula </i>Retz.
<i>Pimpinella anisum </i>Linn.<i> </i>
<i>Azadirachta indica </i>A. Juss.<i> </i>
<i>Shigella</i> <i>dysenteriae</i>
Shigellocidal activity
Central India
Issue Date: Oct-2008
Publisher: CSIR
Series/Report no.: <b style="">Int. cl.<sup>8</sup>-</b>A61K 36/00, A61P 1/00, A61P 31/00
Abstract: The present study has been conducted to evaluate the shigellocidal activity of traditional folk medicine used by tribal people of Mahakoshal region in Central India for the treatment of infectious diseases. Shigellocidal activity was detected using disc diffusion assay and TLC bioautography. In the search for bioactive compounds, aqueous, ethanol, chloroform and acetone extracts of 25 Indian folklore medicinal plants were screened for shigellocidal property. The shigellocidal activity was observed in ethanolic extract of <b style=""><i>Saraca</i></b><b style=""><i> asoca </i>(Roxb.) De Wilde</b><i> </i>syn.<i> Saraca indica auct non</i> Linn., <b style=""><i>Bacopa</i></b><b style=""><i> monnieri </i>(Linn.) Penn.</b>, <b style=""><i>Zingiber</i></b><b style=""><i> officinale </i>Rosc</b><i>.</i>, and <b style=""><i>Terminalia</i></b><b style=""><i> chebula </i>Retz.</b><i> </i>with the MIC range of 5-10 mg/ml, 5-15mg/ml, 5-15mg/ml and 5-10mg/ml, respectively. While chloroform extract of <b style=""><i>Pimpinella</i></b><b style=""><i> anisum</i></b><i> </i><b style="">Linn.</b><i> </i>and<i> <b style="">Azadirachta</b><b style=""> indica </b></i><b style="">A. Juss.</b><i> </i>showed shigellocidal activity with MIC range between<i> </i>5-10mg/ml and 5-20mg/ml, respectively. The active antibacterial compounds analysed by bioautography, were further confirmed by High Performance Liquid Chromatography (HPLC). It is concluded that the crude chloroform extract of <b style=""><i style="">P</i>.<i style=""> anisum</i></b> (seed) containing saponin, exhibited maximum shigellocidal activity at 10mg/ml concentration with 8-12 mm inhibitory zone against all the isolates of <i style="">Shigella</i><i style=""> dysenteriae</i>. Thus, this plant can be used as potential source of natural antimicrobial against <i>Shigella</i> <i>dysenteriae</i>.
Description: 426-436
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.7(5) [September-October 2008]

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