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Title: Silica sulfuric acid catalyzed green synthesis of 1,2- dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2- dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents
Authors: Zhimomi, Betokali K
Imchen, Putusenla
Thurr, Metsütu
Tumtin, Shokip
Phucho, Tovishe
Keywords: Oxazine;Naphthooxazinones;SSA;Solventless;Microwave
Issue Date: Apr-2021
Publisher: NISCAIR-CSIR, India
Abstract: A simple, efficient and green method for the preparation of naphthooxazinones employing easily available reagents 2-naphthol, aldehydes, urea and silica sulphuric acid (SSA) as catalyst is reported. The microwave assisted multi component reaction (MCR) procedure provides multiple advantages inclusive of short reaction times, high yields, easy work-up, catalyst recovery and reusability which proves to be environmentally benign. Studies on the antibacterial properties of the synthesized heterocyclic compounds have been done through in vitro methods against gram-positive and gram-negative bacteria.
Page(s): 598-604
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(04) [April 2021]

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