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Title: In vitro antimicrobial and antioxidant studies on Enicostemma axillare (Lam.) Raynal. leaves
Authors: Deore, Sharada L
Khadabadi, S S
Bhagure, Lalita
Ghorpade, D S
Keywords: Enicostemma axillare;Enicostemma littorale;Chota chirayita;Antimicrobial activity;In vitro antioxidant activity;DPPH method;Nitric oxide method
Issue Date: Oct-2008
Publisher: CSIR
IPC Code: Int. cl.8 - A61K 36/00, A61P 31/00, A61P 31/04, A61P 31/10, A61P 17/18
Abstract:  Enicostemma axillare (Lam.) Raynal. syn. E. littorale Blume (Family ¾ Gentianaceae) is a perennial herb found throughout the greater part of India. Locally it is known as chota chirayita and used in indigenous medicines in the treatment of fevers and as bitter tonic and forms one of ingredients of many hypoglycemic marketed formulations. In the present in vitro antimicrobial activity (Well diffusion method) of aqueous, hydro alcoholic, methanolic, chloroform and ethyl acetate extract of leaves of this plant has been evaluated. Six bacterial species and two fungal strains used for study are: Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, Shigella sonni, Aspergillus niger and Candida albicans. It was observed that chloroform, ethyl acetate and hydroalcoholic extract showed prominent antimicrobial activity against all microorganisms. In vitro antioxidant activity of each extract except ethyl acetate and the possible mechanism involved was investigated by using two different model covering nitric oxide and DPPH method. The result indicated efficacy of extracts for antioxidant activity in following sequence: methanol>hydro alcoholic>aqueous>chloroform.
Page(s): 409-412
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.7(5) [September-October 2008]

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