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Title: Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]
Authors: Biswas, Chinmoy
Chatterjee, Arnab
Sreekumar, Sreelekshmi
Kiran, Manikantan Syamala
Ghosh, Rajarshi
Keywords: Cu(II);Zn(II);Thiosemicarbazone;X-ray structure;Anticancer activity
Issue Date: Apr-2021
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]2 (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC50 value of the complex is measured as 0.72 mM which is lower than that of cisplatin against A549.
Page(s): 531-537
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.60A(04) [April 2021]

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