Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5690
Title: Protective effect of hesperidin on nicotine induced toxicity in rats
Authors: Balakrishnan, Annida
Menon, Venugopal P
Keywords: Free fatty acids
Hesperidin
Lipids
Lipid peroxidation
Nicotine
Issue Date: Feb-2007
Publisher: CSIR
Abstract: Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate dehydrogenase and elevated levels of cholesterol, triglycerides, phospholipids and free fatty acids in Wistar rats. There was a significant protection by hesperidin administration at different doses (25, 50, 75, 100 and 150 mg/kg body weight) in nicotine-treated rats. However, the effect of hesperidin was more significant at 25mg/kg dose. The results suggest that hesperidin exerts the protective effects by modulating the extent of lipid peroxidation. The results are supported by histopathological observations of lung, liver and kidney.
Description: 194-202
URI: http://hdl.handle.net/123456789/5690
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(02) [February 2007]

Files in This Item:
File Description SizeFormat 
IJEB 45(2) 194-202.pdf397.87 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.