Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5681
Title: Blood flow regulation in the cerebral microvasculature with an arcadal network: A numerical simulation
Authors: Niimi, Hideyuki
Komai, Yutaka
Yamaguchi, Saburo
Keywords: Arcadal network
Cerebral microcirculation
Flow-induced response
Flow regulation
Numerical simulation
Issue Date: Jan-2007
Publisher: CSIR
Abstract: Blood flow regulation in the cerebral microvasculature with an arcadal network was investigated using a numerical simulation. A mathematical model for blood flow in the arcadal network, based on <i style="">in vivo</i> data of cat cerebral microvasculature and flow velocity was developed. The network model consists of 45 vessel segments and 25 branching points. To simulate microvascular response to blood flow, non-reactive (solid), cerebral arteriole-like, or skeletal muscle arteriole-like responses to wall shear stress were taken into account. Numerical calculation was carried out in the flow condition where the inlet (arterial) pressure was changed from 60 to 120 mmHg. Flow-rate in each efferent vessel and the mean flow-rate over all efferent vessels were evaluated for assessment of blood supply to the local area of cerebral tissue. The simulation demonstrated the wall shear stress-induced vasodilation in the<i style=""> </i>arcadal<i style=""> </i>network<i style=""> </i>worked to<i style=""> maintain </i>the blood flow at a constant level with pressure variable in a wide range. It is suggested that an individual microvessel (segment) should join in the regulatory process of flow, interacting with other microvessels (<i style="">cooperative regulation</i>).
Description: 41-47
URI: http://hdl.handle.net/123456789/5681
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(01) [January 2007]

Files in This Item:
File Description SizeFormat 
IJEB 45(1) 41-47.pdf211.12 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.