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NPR Vol.7 [2008] >
NPR Vol.7(2) [March-April 2008] >


Title: Antimicrobial activity of methanol extracts of Plumeria acuminata Ait. leaves and Tephrosia purpurea (Linn.) Pers. roots
Authors: Gupta, M
Mazumder, U K
Gomathi, P
Selvan, V Thamil
Keywords: Plumeria acuminata
Tephrosia purpurea
Antimicrobial activity
Agar disc diffusion method
Issue Date: Apr-2008
Publisher: CSIR
IPC CodeInt. cl.8— A61K 36/00, A61K 36/24, A61K 36/48, A61P 31/00, A61P 31/04, A61P 31/10
Abstract: Methanol extract of leaves of Plumeria acuminata Ait. (MEPA) and roots of Tephrosia purpurea (Linn.) Pers. (METP) were investigated for their in vitro antimicrobial properties by agar disc diffusion method. The crude methanolic extracts MEPA and METP inhibited the growth of both Gram positive bacteria (Bacillus subtilis, Staphylococcus aureuspers.and Micrococcus luteus) and Gram negative bacteria (Escherichia coli, Pseudomsonas aeruginosa and Salmonella typhimurium). The Gram positive bacteria tested appeared to be more susceptible to the extracts than the Gram negative bacteria. Both the extracts at the concentration ranging between 250 μg/ml and 1000 μg/ml showed inhibitory activity against all tested bacteria except MEPA which did not show activity against S. typhimurium at 250 μg/ml concentration. At 100 μg/ml concentration. MEPA was found neutral against M. luteus, E. coli, P. aeruginosa and S. typhimurium while METP was neutral against E. coli and P. aeruginosa at same concentration. The extracts also showed significant antifungal activity against Aspergillus niger and Candida albicans. All tested microorganisms showed dose dependent susceptibility towards the methanol extracts. The antibacterial and antifungal activity of the extracts and standard drugs were statistically significant. Based on the current findings, it can be concluded that both the plants possess potent antimicrobial activity.
Page(s): 102-105
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.7(2) [March-April 2008]

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