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NPR Vol.7(1) [January-February 2008] >


Title: Phytochemical composition and antioxidant potential of Desmodium gangeticum (Linn.) DC.
Authors: Niranjan, A
Tewari, S K
Keywords: Desmodium gangeticum
lupeol
lauric acid
stigmasterol
phenolic content
antioxidant activity
Oxidative DNA damage
Issue Date: Feb-2008
Publisher: CSIR
IPC CodeInt. cl.8 A61K 36/00, A61P 39/06
Abstract: Chemical examination of Desmodium gangeticum (Linn.) DC. root and aerial parts has resulted into lupeol, lauric acid and mixture of β-sitosterol and stigmasterol. The total phenolic contents (TPC) were 14.4, 13.8 mg/g GAE; antioxidant activity (AOA) 58.9, 54.8% and reducing power (RP) in terms of ascorbic acid equivalent (ASE/ml) 2.7 and 2.9 in roots and aerial parts of the plant, respectively. Free radical scavenging activity (FRSA) measured by , -diphenyl-β-picrylhydrazyl (DPPH) showed IC50 (Inhibitory Concentration) 0.31, 0.35 mg/ml; EC50 (Efficient Concentration) 13.48, 15.22mg/mg DPPH and ARP (Antiradical Power) 7.42, 6.57 in roots and aerial parts, respectively. AOA in different assays expressed as IC50 in aforesaid plant parts ranged from 0.27-0.83 mg/ml and 0.41-1.11 mg/ml, respectively. The extract of both parts showed significant protective effect against Fenton’s reaction on supercoiled pUC 18 DNA assayed by agarose gel electrophoresis. The specific phenolic composition assayed through HPLC and MS/MS showed the presence of gallic, protocatechuic, salicylic, chlorogenic, caffeic acids, rutin, quercetin and kaempferol in both parts of plant.
Page(s): 35-39
ISSN: 0975-1092 (Online); 0972-592X (Print)
Source:NPR Vol.7(1) [January-February 2008]

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