Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5642
Title: Phytochemical composition and antioxidant potential of <i>Desmodium gangeticum</i> (Linn.) DC.
Authors: Niranjan, A
Tewari, S K
Keywords: <i>Desmodium gangeticum</i>
lupeol
lauric acid
stigmasterol
phenolic content
antioxidant activity
Oxidative DNA damage
Issue Date: Feb-2008
Publisher: CSIR
Series/Report no.: Int. cl.<sup>8</sup>—<b></b> A61K 36/00, A61P 39/06
Abstract: Chemical examination of <b><i>Desmodium gangeticum</i></b> (<b>Linn.</b>) <b>DC.</b> root and aerial parts has resulted into lupeol, lauric acid and mixture of β-sitosterol and stigmasterol. The total phenolic contents (TPC) were 14.4, 13.8 mg/g GAE; antioxidant activity (AOA) 58.9, 54.8% and reducing power (RP) in terms of ascorbic acid equivalent (ASE/ml) 2.7 and 2.9 in roots and aerial parts of the plant, respectively. Free radical scavenging activity (FRSA) measured by <img src='/image/spc_char/alpha.gif'> ,<img src='/image/spc_char/alpha.gif'> -diphenyl-β-picrylhydrazyl (DPPH) showed IC<sub>50</sub> (Inhibitory Concentration) 0.31, 0.35 mg/ml; EC<sub>50</sub> (Efficient Concentration) 13.48, 15.22mg/mg DPPH and ARP (Antiradical Power) 7.42, 6.57 in roots and aerial parts, respectively. AOA in different assays expressed as IC<sub>50</sub> in aforesaid plant parts ranged from 0.27-0.83 mg/ml and 0.41-1.11 mg/ml, respectively. The extract of both parts showed significant protective effect against Fenton’s reaction on supercoiled pUC 18 DNA assayed by agarose gel electrophoresis. The specific phenolic composition assayed through HPLC and MS/MS showed the presence of gallic, protocatechuic, salicylic, chlorogenic, caffeic acids, rutin, quercetin and kaempferol in both parts of plant.
Description: 35-39
URI: http://hdl.handle.net/123456789/5642
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.7(1) [January-February 2008]

Files in This Item:
File Description SizeFormat 
NPR 7(1) 35-39.pdf93.08 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.