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Title: Synthesis, in silico pharmacokinetic analysis and anticancer activity evaluation of benzothiazole-triazole hybrids
Authors: Rawat, Srishti
Rawat, Diwan S
Negi, Beena
Keywords: 2-Aminobenzothiazole;Triazole;Renal cancer;Hybrid;Click chemistry
Issue Date: Mar-2021
Publisher: NISCAIR-CSIR, India
Abstract: Over the past decade, a variety of benzothiazole derivatives have been reported with promising anticancer activity. Benzothiazole and its analogues are capable of acting on a number of molecular targets and thus exerting their anticancer activity. To further develop benzothiazole derivatives as anticancer agents, we attempted to design and synthesize a library of benzothiazole-triazole derivatives. The synthesized hybrid compounds have been selected by National Cancer Institute, USA for the in┬ávitro activity evaluation against 60 human cancer cell lines in a one dose screening panel. Most of the synthesized compounds showed 60-80% growth rate against renal cancer cell line UO-31.
Page(s): 409-417
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(03) [March 2021]

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