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Title: Synthesis and antimicrobial activity of chalcone containing polystyrene
Authors: Rain, Farhana Sumi
Hasan, Tariqul
Chowdhury, Samiul Islam
Ali, Roushown
Keywords: Chalcone;4-propargyloxychalcone;Azide end-functional polystyrene;Chalcone containing polystyrene;Click reaction;Antibacterial activity
Issue Date: Mar-2021
Publisher: NISCAIR-CSIR, India
Abstract: Three different 4-propargyloxychalcones have been prepared starting from 4-propargyloxy benzaldehyde and chalcones with proper chemical transformation. Polystyrenes containing biologically active chalcone moiety in their structures have been successfully synthesised by the Click reaction from the 4-propargyloxychalones (terminal alkyne) and azido end-functional polystyrene (PS-N3). All the desired products have been obtained with good yield and purity. The structure of the 4-propargyloxychalcones and the chalcone containing polystyrenes have been characterized by FT-IR, 1H NMR and UV-Vis spectroscopy. The antibacterial activity of the synthesized 4-propargyloxychalcones their polystyrene derivatives have been evaluated against two bacterial strains, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results reveal that the tested chalcones and their polystyrene derivatives have moderate antimicrobial activity.
Page(s): 456-464
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(03) [March 2021]

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