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Title: Antiulcerogenic and antioxidant effects of Coccinia grandis (Linn.) Voigt leaves on aspirin-induced gastric ulcer in rats
Authors: Mazumder, Papiya Mitra
Sasmal, D
Nambi, R Arivudai
Keywords: Ivy Gourd;Coccinia grandis;Gastric ulcer;Antiulcerogenic;Antioxidant
Issue Date: Feb-2008
Publisher: CSIR
IPC Code: Int. cl.8— A61K 36/00, A61K 36/42, A61K 127/00, A61P 1/04.
Abstract: The effect of Coccinia grandis (Linn.)Voigt leaves powder, its methanol and aqueous extracts were investigated on aspirin-induced gastric ulcer model in rats. The leaf powder showed a significant dose related decrease in ulcer index, with significant increase in mucus secretion and decrease in level of Lipid peroxidation (LPO) and Superoxide dismutase (SOD) activity. Methanol extract at an equivalent dose to that of the powder also showed a significant decrease in ulcer index with significant changes in mucus secretion, LPO and SOD. However, aqueous extract was found to be non-significant in reducing ulcer index. The group, receiving standard drug Famotidine, showed no effect on the mucus secretion induced in this experimental model. These observations confirm the antiulcerogenic potential of this plant, probably due to increased mucus secretion and antioxidant property.
Page(s): 15-18
ISSN: 0975-1092 (Online); 0972-592X (Print)
Appears in Collections:NPR Vol.7(1) [January-February 2008]

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