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Title: Quantitative structure activity relationship study of pyrazole ligands binding to estrogen receptor- -selective agonists
Authors: Srivastava, Soumya
Srivastava, S K
Keywords: quantitative structure - activity relationship
estrogen receptors
tetrasubstituted pyrazoles
Issue Date: Jan-2005
Publisher: CSIR
IPC CodeInt. Cl.7 A 61 K 38/00; C 07 D 231/00
Abstract: A quantitative structure activity relationship (QSAR) study on tetrasubstituted pyrazoles as high affinity ligands for the estrogen receptor (both ER and ERβ subtypes) have been performed using various combinations of hydrophobic (MlogP), steric (MR) and electronic (Xeq) descriptors. The regression analysis of the data has shown better results in multiparametric regressions upon introduction of dummy parameters (indicator variables). The results suggest that the binding affinity for ER and ERβ subtypes in tetrasubstituted pyrazoles is largely enhanced by the negative coefficient of MlogP and positive coefficient of MR descriptors.
Page(s): 122-126
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.04(1) [January 2005]

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